You have reached the TargetTranslator, an interactive tool that enables the creation of gene signatures and exploration of their connections to different compounds.
TargetTranslator is currently in beta and new functionality will be added continuously.
Upload your own dataset and/or add data from the preprocessed ones.
If you upload your own data, make sure to follow our formatting guidelines.
| Rank | Perturbation | Score | FDR | Direction |
|---|
This table tells you what drugs are most likely to induce the change you wanted to investigate.
Example:
Let's say you have a variable x that can take on the values 0 and 1, corresponding to low and high risk respectively. Then the table will contain the drugs that will most likely change a high risk gene signature to a low risk gene signature (direction: positive) and vice versa.
This table contains protein targets as defined by the STITCH database. The top ranking targets are those that seems to be enriched in the drug scoring table.
Each target has an associated empirical cumulative distribution functions (ECDF), visible when hovering the target row. This makes it easy to compare the ECDF of the target and the ECDF of all other targets.
| Target | D-value | p-value | Direction |
|---|
link to FAQ
link to videos
link to heavy documentation
link to algorithm overview
Troubleshooting
Please make sure that you data is correctly formatted, i.e. with unique row and column identifiers.
If cox seems fishy, decrease the selected stratifications to below 20.
Make sure that your expression values are normally distributed, otherwise, try to log2 transform the data before submitting them for analysis.
download the r package
give link to cran repository
link to user guide for the package
link to publication
link to the group website
some contact information